RICHTER CycleBalance®

Efficacy/ benefits

RICHTER CycleBalance® is a clinically tested formulation developed by doctors that naturally regulates female sex cycle and hormones, which are the key to pregnancy for women with or without PCOS. It contributes to the correct functioning of the ovary but also corrects metabolic disorders.

Effect on cycle problems

72%

maintained normal ovulation with RICHTER CycleBalance® treatment in women with PCOS which means a significantly higher chance to get pregnant¹.

Effect on fertility problems

2.5

times higher pregnancy rate with RICHTER CycleBalance® treatment in women with PCOS during IVF procedure².

Effect on fertility problems for woman without PCOS

Improves egg cell even
in Non-PCOS women

During IVF procedure with CycleBalance® treatment, also significantly lower amount of hormone (rFSH) was enough for conception among women without PCOS, because CycleBalance improves oocyte quality in women³.

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Effect on Insulin sensitivity:

56%

improved insulin sensitivity using RICHTER CycleBalance® in women with PCOS⁴.

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RICHTER CycleBalance® is an effective and safe therapy. Capable of restoring spontaneous menstrual cycle, ovarian activity and elevates fertilization rate among women with or without PCOS. This therapy did not cause multiple pregnancy.

Effect on Gestational Diabetes:

65%

risk reduction of Gestational Diabetes in women with risk of developing diabetes if RICHTER CycleBalance® was taken⁵.

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¹Papaleo, Enrico; Unfer, Vittorio; Baillargeon, Jean-Patrice; Santis, Lucia de; Fusi, Francesco; Brigante, Claudio et al. (2007): Myo-inositol in patients with polycystic ovary syndrome. A novel method for ovulation induction. In Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 23 (12), pp. 700–703. DOI: 10.1080/09513590701672405.

²Artini, Paolo; Di M Berardino, O.; Papini, F.; Genazzani, Alessandro; Simi, G.; Ruggiero, M.; Cela, Vito (2013): Endocrine and clinical effects of Myo-Inositol administration in polycystic ovary syndrome. A randomized study. In Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 29. DOI: 10.3109/09513590.2012.743020.

³Lisi, Franco; Carfagna, Piero; Oliva, Mario Montanino; Rago, Rocco; Lisi, Rosella; Poverini, Roberta et al. (2012): Pretreatment with myo-inositol in non polycystic ovary syndrome patients undergoing multiple follicular stimulation for IVF. A pilot study. In Reproductive Biology and Endocrinology : RB&E 10, p. 52. DOI: 10.1186/1477-7827-10-52.

⁴Artini, Paolo; Di M Berardino, O.; Papini, F.; Genazzani, Alessandro; Simi, G.; Ruggiero, M.; Cela, Vito (2013): Endocrine and clinical effects of Myo-Inositol administration in polycystic ovary syndrome. A randomized study. In Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 29. DOI: 10.3109/09513590.2012.743020.

RICHTER CycleBalance® has proven other positive effects in the treatment of different features:

•May correct metabolic disorders that contribute to ovarian dysfunction¹, ²
•Studies demonstrate it improves oocyte quality³
•Doctor-designed especially for women with Polycystic Ovary Syndrome (PCOS)
•Can help during natural ways of trying to get pregnant and even during medically aided ways
•Improves oocyte numbers and quality in IVF cycles
•A simple and safe treatment capable of restoring spontaneous ovarian activity
•It is of vegetable origin (gluten or lactose free) and without unpleasant side effects.
•Reduces of insulin resistance, improves insulin sensitivity
•Brought to you by Gedeon Richter, an expert company in Gynaecology in more than 100 years with special knowledge in
fertility and myoma treatment.

¹Unfer, Vittorio; Facchinetti, Fabio; Orrù, Beatrice; Giordani, Barbara; Nestler, John (2017): Myo-inositol effects in women with PCOS. A meta-analysis of randomized controlled trials. In Endocrine Connections 6 (8), pp. 647–658. DOI: 10.1530/EC-17-0243.

²Costantino, D.; Minozzi, G.; Minozzi, E.; Guaraldi, C. (2009): Metabolic and hormonal effects of myo- inositol in women with polycystic ovary syndrome: a double-blind trial. In European review !or medical and pharmacological sciences 13 (2), pp. 105–110.

³Papaleo, Enrico; Unfer, Vittorio; Baillargeon, Jean-Patrice; Fusi, Francesco; Occhi, Francesca; Santis, Lucia de (2009): Myo-inositol may improve oocyte quality in intracytoplasmic sperm injection cycles. A prospective, controlled, randomized trial. In Fertility and sterility 91 (5), pp. 1750–1754. DOI: 10.1016/j.fertnstert.2008.01.088.

Other benefits:

•Does not cause multiple pregnancies
•Reduction of hirsutism
•Improving acne and skin problems
Click for more benefits of active substances

How CycleBalance® works?

How myo-inositol in RICHTER CycleBalance® works? Mechanism of action: Elevated insulin hormone level in the blood (hyperinsulinemia) is a common metabolic disorder, Hyperinsulinemia and insulin resistance affects more than 1 out of 4 people¹,². Insulin resistance and the compensatory hyperinsulinemia affects some 65–70% of women with PCOS (Polycystic ovary syndrome) and cycle problems³.

Hyperinsulinemia works against egg development and ovulation by increasing male hormone production in the ovary. PCOS is associated with androgen (male hormone) excess in the ovary which is responsible for anovulation and polycystic ovaries.⁴
• All insulin-lowering treatments including weight loss, have beneficial effects on excessive male hormone production and ovulation.

CycleBalance® acts as an insulin-sensitizing agent, with its active compound myo-inositol helps to correct metabolic disorder of Hyperinsulinemia. Proper utilization of hormone insulin balances other hormones which control cycle, this way helping in re-starting ovulation, in naturally regulating cycle and in egg development that are key to getting pregnant.

• Although male hormone excess stimulates follicle growth, it inhibits the selection of the dominant egg cell; thus, it can lead to the accumulation of undeveloped follicles, that is, to the development of “polycystic” ovaries where the name PCOS comes from.⁵

• The elevated luteinizing hormone (LH) levels increase the production and secretion of male hormones in the ovaries which play a role in the development of PCOS.⁶

• A more complex way of explanation: hyperinsulinemia works against egg development and ovulation by increasing luteinizing hormone (LH) dominance over follicle-stimulating hormone (FSH), while for ovulation and development of egg cell it should change to be vica versa in every cycle. Your body is kept at the beginning of the cycle, so there is no ovulation.

• Cycle starts with LH dominance but there is a change around day 9-10, where FSH dominates. Too high insulin level eliminates this cyclicity, it preserves the situation at the beginning of the cycle, so basically there is no menstrual cycle, no maturation of eggs and no ovulation.

Phases of the Ovarian Circle

Follicular Phase

Luteal Phase

FSH LH

Primary Follicle Theca Antrum Ovulation Corpus Luteum Formation Mature Corpus Luteum Corpus Albicans

Oestrogen Inhibin Progesteron

Phases of the Uterine Circle

Menses

Proliferative Phase

Secretory Phase

Days

¹Li, Chaoyang; Ford, Earl S.; McGuire, Lisa C.; Mokdad, Ali H.; Little, Randie R.; Reaven, Gerald M. (2006): Trends in hyperinsulinemia among nondiabetic adults in the U.S. In Diabetes Care 29 (11), pp. 2396–2402. DOI: 10.2337/dc06-0289.
²Ioannou, George N.; Bryson, Chris L.; Boyko, Edward J. (2007): Prevalence and trends of insulin resistance, impaired fasting glucose, and diabetes. In Journal of diabetes and its complications 21 (6), pp. 363–370. DOI: 10.1016/j.jdiacomp.2006.07.005.
³Marshall, John C.; Dunaif, Andrea (2012): All Women With PCOS Should Be Treated For Insulin Resistance. In Fertility and sterility 97 (1), pp. 18–22. DOI: 10.1016/j.fertnstert.2011.11.036.
⁴McMaster Pathophysiology Review (MPR), 2013
⁵Jonard, Sophie; Dewailly, Didier (2004): The follicular excess in polycystic ovaries, due to intra-ovarian hyperandrogenism, may be the main culprit for the follicular arrest. In Human reproduction update 10 (2), pp. 107–117. DOI: 10.1093/humupd/dmh010
⁶Taylor, A. E.; McCourt, B.; Martin, K. A.; Anderson, E. J.; Adams, J. M.; Schoenfeld, D.; Hall, J. E. (1997): Determinants of abnormal gonadotropin secretion in clinically defined women with polycystic ovary syndrome. In The Journal of clinical endocrinology and metabolism 82 (7), pp. 2248–2256. DOI: 10.1210/jcem.82.7.4105.

The folic acid present in RICHTER CycleBalance® helps reduce the risk neural tube defects in the baby if you do get pregnant with RICHTER CycleBalance®.

¹ Papaleo, Enrico; Unfer, Vittorio; Baillargeon, Jean-Patrice; Santis, Lucia de; Fusi, Francesco; Brigante, Claudio et al. (2007): Myo-inositol in patients with polycystic ovary syndrome. A novel method for ovulation induction. In Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 23 (12), pp. 700–703. DOI: 10.1080/09513590701672405.

² Artini, Paolo; Di M Berardino, O.; Papini, F.; Genazzani, Alessandro; Simi, G.; Ruggiero, M.; Cela, Vito (2013): Endocrine and clinical effects of Myo-Inositol administration in polycystic ovary syndrome. A randomized study. In Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 29. DOI: 10.3109/09513590.2012.743020.

³ Lisi, Franco; Carfagna, Piero; Oliva, Mario Montanino; Rago, Rocco; Lisi, Rosella; Poverini, Roberta et al. (2012): Pretreatment with myo-inositol in non polycystic ovary syndrome patients undergoing multiple follicular stimulation for IVF. A pilot study. In Reproductive Biology and Endocrinology : RB&E 10, p. 52. DOI: 10.1186/1477-7827-10-52.

⁴ Artini, Paolo; Di M Berardino, O.; Papini, F.; Genazzani, Alessandro; Simi, G.; Ruggiero, M.; Cela, Vito (2013): Endocrine and clinical effects of Myo-Inositol administration in polycystic ovary syndrome. A randomized study. In Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 29. DOI: 10.3109/09513590.2012.743020.

Active substances of CycleBalance

Myo-inositol (2g):

Inositol was first identified in the leaves of a plant called Bougainvillea spectabilis and commonly found in fruits (grapefruit the highest), vegetables (leafy vegetables the lowest) and seeds (beans, almonds &
walnuts the highest). In order to help menstrual cyclicity, support ovulatory function, oocyte quality besides normal diet gynaecology experts at Gedeon Richter recommend to take extra supplementation.

Myo-inositol (2g in CycleBalance®, Source: Zea mays (Whole))

•Affects the cellular response to insulin
•Extensive literature in fertility and oocyte quality
•Important part of cell wall and biochemical mediators of the body
Major role in:¹
- •Morphogenesis and cell growth
- •Lipids synthesis
- •Structure of cell membranes
- Folic acid (200µg in CycleBalance®, Source: Synthetic)
•Major role in growing and quickly dividing cells
•Lowers the risk of birth defects, notably neural tube defects²(NTDs) – important to take if you get pregnant with the help of CycleBalance®

¹ Dinicola, Simona; Chiu, Tony T. Y.; Unfer, Vittorio; Carlomagno, Gianfranco; Bizzarri, Mariano (2014): The rationale of the myo-inositol and D-chiro-inositol combined treatment for polycystic ovary syndrome. In Journal of clinical pharmacology 54 (10), pp. 1079–1092. DOI: 10.1002/jcph.362.

² Ami, Noam; Bernstein, Mark; Boucher, François; Rieder, Michael; Parker, Louise (2016): Folate and neural tube defects.
The role of supplements and food fortification. In Paediatrics & Child Health 21 (3), pp. 145–149.

Ingredients
myo-inozitol	2000 mg	*
folic acid	200 µg	100

Dosage:

Dosage: 1-2 sachets per day for adults dissolved in a glass of water or another liquid. The powder can be taken directly into the mouth as well.

Warning:

The dietary supplement does not substitute a balanced, mixed diet and a healthy lifestyle.
The recommended daily dosage must not be exceeded!
Keep out of the reach of children!
Do not use with a known hypersensitivity to any of the ingredients!

Storage Conditions:

Protect from light, moisture and heat. Store at room temperature.

The quality is assured until the date indicated on the packaging.

Where to get it?

Gedeon Richter pharmaceutical company

Gedeon Richter producer of RICHTER CycleBalance® is an expert company in Women Healthcare in more than 100 years with special knowledge in fertility and myoma treatment.

Gynaecology experts at Gedeon Richter recommend to take extra supplementation besides normal diet in order to help menstrual cyclicity, support ovulatory function and oocyte quality.